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Review
. 2002 Nov 4;87(10):1057-65.
doi: 10.1038/sj.bjc.6600625.

Role of genetic polymorphisms in tumour angiogenesis

S P Balasubramanian  1 , N J Brown, M W R Reed
Affiliations
Review

Role of genetic polymorphisms in tumour angiogenesis

S P Balasubramanian et al. Br J Cancer. .

Abstract

Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed.

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