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. 2002 Nov 15;186(10):1526-9.
doi: 10.1086/344353. Epub 2002 Oct 23.

Viable but nonculturable Salmonella species recovery and systemic infection in morphine-treated mice

Hiroshi Asakura  1 , Masahisa Watarai, Toshikazu Shirahata, Sou-Ichi Makino
Affiliations

Viable but nonculturable Salmonella species recovery and systemic infection in morphine-treated mice

Hiroshi Asakura et al. J Infect Dis. .

Abstract

In vivo recovery and pathogenicity of Salmonella enterica serovar Oranienburg that became viable but nonculturable (VNC) in food were examined. VNC cells were completely eliminated in normal mice but caused systemic bacteremia and were subsequently lethal to morphine-treated mice. Therefore, morphine-treated mice might be a useful bioassay for VNC Salmonella species in implicated food items.

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