Airway inflammation and remodeling in asthma: current concepts

Abstract

Asthma is a chronic inflammatory disorder of the airways interacting with altered structure and function of the formed elements including smooth muscle. While atopy and polarization of the airway T-cell response toward a Th-2 phenotype are important factors in asthma pathogenesis, there is increasing realization that remodeling events are also important. Evidence is presented that inflammation and altered airway structure in asthma interact through the epithelium and underlying mesenchyme. As in other chronic inflammatory disorders, a dynamic interplay between mediators, cytokines, and growth factors provides a broader base on which to identify novel preventative and therapeutic strategies in asthma.