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Comment
. 2002 Oct 24;36(3):338-40.
doi: 10.1016/s0896-6273(02)01006-1.

mRNA at synapses, synaptic plasticity, and memory consolidation

Oswald Steward  1
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Free article
Comment

mRNA at synapses, synaptic plasticity, and memory consolidation

Oswald Steward. Neuron. .
Free article

Abstract

Miller et al. (this issue of Neuron) report that deletion of the 3'UTR of alpha-CaMKII mRNA prevents dendritic delivery of the mRNA in transgenic mice and thus local synthesis of alpha-CaMKII protein in dendrites. 3'UTR mutant mice exhibit decreases in alpha-CaMKII protein in postsynaptic densities, and deficits in late phase LTP and in memory consolidation.

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