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Review
. 2002 Nov 15;8(22):5066-71.
doi: 10.1002/1521-3765(20021115)8:22<5066::AID-CHEM5066>3.0.CO;2-0.

Chemical approaches untangling sequence-specific DNA binding by proteins

Shin-ichi Sato  1 , Masaki Hagihara, Kenji Sugimoto, Takashi Morii
Affiliations
Review

Chemical approaches untangling sequence-specific DNA binding by proteins

Shin-ichi Sato et al. Chemistry. .

Abstract

Structure-based design of novel DNA-binding proteins provides an ultimate test of our understanding of protein-DNA interactions. A combination of synthetic, organic, biochemical and molecular biological approaches has been developed to study the principle of molecular recognition associated with the protein-DNA interactions. The strategies enabled a specific formation of noncovalent peptide dimers and determination of the preferential DNA-binding sequence of short peptides.

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