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Review
. 2002 Oct;6(5):577-82.
doi: 10.1016/s1367-5931(02)00365-4.

Fatty acid desaturation: variations on an oxidative theme

Behnaz Behrouzian  1 , Peter H Buist
Affiliations
Review

Fatty acid desaturation: variations on an oxidative theme

Behnaz Behrouzian et al. Curr Opin Chem Biol. 2002 Oct.

Abstract

Significant progress in our understanding of the mechanism of fatty acid desaturation has been achieved. The site of initial oxidation has been determined for several membrane-bound desaturases and a common cryptoregiochemical theme has been revealed. The results of several studies, including a detailed analysis of a soluble plant desaturase system, point to a close mechanistic relationship between dehydrogenation and hydroxylation pathways.

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