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Review
. 2002 Nov;20(11):462-6.
doi: 10.1016/s0167-7799(02)02063-2.

In vivo-applied functional RNAs as tools in proteomics and genomics research

Michael Famulok  1 , Sandeep Verma
Affiliations
Review

In vivo-applied functional RNAs as tools in proteomics and genomics research

Michael Famulok et al. Trends Biotechnol. 2002 Nov.

Abstract

Non-natural, functional RNA molecules, such as short interfering (si) RNAs, aptazymes, maxizymes and intramers, allow modulation of gene function at the mRNA or protein level. This review discusses recent advances made in the expression and application of these functional RNAs and illustrates how engineered, intracellularly active RNAs can serve as promising tools for understanding the function of genes and their protein products or as potential therapeutic agents.

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