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. 1975;1(3):285-93.

Behavioral supersensitivity to apomorphine and amphetamine after chronic high dose haloperidol treatment

R C Smith, J M Davis
  • PMID: 1241453

Behavioral supersensitivity to apomorphine and amphetamine after chronic high dose haloperidol treatment

R C Smith et al. Psychopharmacol Commun. 1975.

Abstract

Rats administered chronic haloperidol (5 mg/cc) for 2 months exhibited stereotyped gnawing during chronic haloperidol treatment, and after withdrawal from haloperidol, showed significantly greater stereotyped behavior induced by apomorphine or L-amphetamine compared to saline controls. Chronic administration of benztropine mesylate concomitantly with haloperidol reduced the effects of chronic haloperidol on drug induced stereotyped behavior during the withdrawal period.

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