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. 2002 Sep;18(5-6):410-2.
doi: 10.1007/s00383-002-0830-3. Epub 2002 Apr 25.

Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated

C-H Chiu  1 , L-H Su, C-C He, T-H Jaing, C-C Luo, T-Y Lin
Affiliations

Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated

C-H Chiu et al. Pediatr Surg Int. 2002 Sep.

Abstract

Intestinal perforation, a life-threatening complication of toxic megacolon (TM) following non-typhoid Salmonella infection, is relatively uncommon in infants less than 1 year of age. The situation, also found in typhoid fever, appears to be cytokine-mediated. This finding may justify immunotherapy for older children with TM associated with non-typhoid Salmonella infection in order to prevent this complication.

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