Review
Update on mitochondrial toxicity of antiretrovirals and its link to lipodystrophy
Affiliations
- PMID: 12416448
Item in Clipboard
Review
Update on mitochondrial toxicity of antiretrovirals and its link to lipodystrophy
AIDS Rev.
2002 Jul-Sep.
Abstract
The dramatic improvement seen in the latest years in the prognosis of HIV infection has been threatened by long-term toxicities of antiretroviral drugs. Nucleoside analogs remain the cornerstone of antiretroviral therapy, but these compounds seem to produce mitochondrial damage leading to a broad range of side effects, which depend of the organ/tissue affected. Among those toxicities are of particular concern lipoatrophy and hyperlactatemia syndromes. This review will focus on the pathogenesis of mitochondrion damage caused by nucleoside analogs and its clinical consequences, particularly in respect to body-shape changes.
Similar articles
-
Nucleoside analogues toxicities related to mitochondrial dysfunction: focus on HIV-infected children.Antivir Ther. 2005;10 Suppl 2:M53-64. Antivir Ther. 2005. PMID: 16152706 Review. No abstract available.
-
Long-term complications of nucleoside reverse transcriptase inhibitor therapy.AIDS Read. 2003 Apr;13(4):176-84, 187. AIDS Read. 2003. PMID: 12741368 Review.
-
Evidence for mitochondrial toxicity: lactic acidosis as proof of concept.J HIV Ther. 2001 Mar;6(1):13-6. J HIV Ther. 2001. PMID: 11501196 Review. No abstract available.
-
Complications associated with NRTI therapy: update on clinical features and possible pathogenic mechanisms.Antivir Ther. 2004 Dec;9(6):849-63. Antivir Ther. 2004. PMID: 15651744 Review.
-
Mitochondrial toxicity and lactic acidosis.Proj Inf Perspect. 2000 Mar;(29):10-1. Proj Inf Perspect. 2000. PMID: 12772662
Cited by
-
Optimisation of antiretroviral therapy in HIV-infected children under 3 years of age.Cochrane Database Syst Rev. 2014 May 22;2014(5):CD004772. doi: 10.1002/14651858.CD004772.pub4. Cochrane Database Syst Rev. 2014. PMID: 24852077 Free PMC article.
-
Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.Semin Immunopathol. 2016 Nov;38(6):727-738. doi: 10.1007/s00281-016-0578-9. Epub 2016 Jul 8. Semin Immunopathol. 2016. PMID: 27392971 Review.
-
Mitochondrial DNA content, an inaccurate biomarker of mitochondrial alteration in human immunodeficiency virus-related lipodystrophy.Antimicrob Agents Chemother. 2008 May;52(5):1670-6. doi: 10.1128/AAC.01449-07. Epub 2008 Mar 10. Antimicrob Agents Chemother. 2008. PMID: 18332166 Free PMC article.
-
In vitro and in vivo effects of IGF-I on adiposity in HIV-associated metabolic disease: a pilot study.Arch Med Res. 2013 Jul;44(5):361-9. doi: 10.1016/j.arcmed.2013.06.001. Epub 2013 Jul 16. Arch Med Res. 2013. PMID: 23867790 Free PMC article.
-
Mid-ATR-FTIR spectroscopic profiling of HIV/AIDS sera for novel systems diagnostics in global health.OMICS. 2014 Aug;18(8):513-23. doi: 10.1089/omi.2013.0157. Epub 2014 Jun 17. OMICS. 2014. PMID: 24937213 Free PMC article.