Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Nov;110(9):1219-20.
doi: 10.1172/JCI16780.

The cellular response to aggregated proteins associated with human disease

Affiliations

The cellular response to aggregated proteins associated with human disease

David H Perlmutter. J Clin Invest. 2002 Nov.
No abstract available

PubMed Disclaimer

References

    1. Anfinsen CB. Principles that govern the folding of protein chains. Science. 1973;181:223–230. - PubMed
    1. Horwich A. Protein aggregation in disease: a role of folding intermediates forming specific multimeric interactions. J Clin Invest. 2002;110:1221–1232. doi:10.1172/JCI200216781. - PMC - PubMed
    1. Bucciantini M, et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature. 2002;416:507–511. - PubMed
    1. Selkoe, D.J. 2002. Deciphering the genesis and fate of amyloid-β protein yields novel therapies for Alzheimer disease. J. Clin. Invest. In press. - PMC - PubMed
    1. Walsh DM, et al. Naturally secreted oligomers of amyloid ? protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002;416:535–539. - PubMed

Substances