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Comment
. 2002 Nov;110(9):1239-41.
doi: 10.1172/JCI17051.

Modeling the benefits of pamidronate in children with osteogenesis imperfecta

Robert Lindsay  1
Affiliations
Comment

Modeling the benefits of pamidronate in children with osteogenesis imperfecta

Robert Lindsay. J Clin Invest. 2002 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Proposed mechanism of bisphosphonate (BP) action. BPs inhibit a key step in the hydroxymethylglutaryl conenzyme A (HMG-CoA) reductase pathway through the inhibition of farnesyl-pyrophosphate synthase. Inhibition of protein isoprenylation results in osteoclast apoptosis and inhibition of osteoclast-mediated bone resorption. GTP, guanosine 5′ -triphosphate; PP, pyrophosphate; BMP-2, bone morphogenetic protein–2.
Figure 2
Figure 2
Active osteoclasts mediate bone resorption. Osteoclast absorption of bisphosphonates results in the inhibition of osteoclast function and osteoclast apoptosis.
See this image and copyright information in PMC

Comment on

References

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