Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Oct 29;12(21):R725-7.
doi: 10.1016/s0960-9822(02)01247-2.

Immunoglobulin genes: generating diversity with AID and UNG

Ursula Storb  1 , Janet Stavnezer
Affiliations
Free article
Review

Immunoglobulin genes: generating diversity with AID and UNG

Ursula Storb et al. Curr Biol. .
Free article

Abstract

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.

PubMed Disclaimer

Comment on

Substances

LinkOut - more resources