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. 2002 Dec 2;12(23):3407-11.
doi: 10.1016/s0960-894x(02)00725-4.

Anticancer activity for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and their abilities to interact with lymphoendothelial cell surface markers

Lee Roy Morgan  1 , Branko S Jursic, Catherine L Hooper, Donna M Neumann, Kanappan Thangaraj, Blaise LeBlanc
Affiliations

Anticancer activity for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and their abilities to interact with lymphoendothelial cell surface markers

Lee Roy Morgan et al. Bioorg Med Chem Lett. .

Abstract

The structure of the anticancer agent 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007's moieties. Analogue anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed.

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