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. 2002 Nov;50(11):1479-83.
doi: 10.1248/cpb.50.1479.

1,5-dimethyl-6H-pyridazino[4,5-b]carbazole, a 3-aza bioisoster of the antitumor alkaloid olivacine

Norbert Haider  1 , Eddy Sotelo
Affiliations
Free article

1,5-dimethyl-6H-pyridazino[4,5-b]carbazole, a 3-aza bioisoster of the antitumor alkaloid olivacine

Norbert Haider et al. Chem Pharm Bull (Tokyo). 2002 Nov.
Free article

Abstract

A series of b-fused carbazoles structurally related to pyrido[4,3-b]carbazole-type alkaloids was prepared, utilizing the Diels-Alder reaction of 1-methylpyrano[3,4-b]indol-3(9H)-one with electron-deficient acetylenic dienophiles as the key step. The title compound (14) thus obtained in only four steps represents a new 3-aza analog of the antitumor natural product, olivacine.

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