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. 2002 Sep;69(9):761-4.
doi: 10.1007/BF02723686.

Detecting protein losing enteropathy by Tc-99m dextran scintigraphy: a novel experience

Seema Kapoor  1 , Simmi K Ratan, Ravi Kashyap, S K Mittal, K Rajeshwari, H Rawat, Jyoti Verma
Affiliations

Detecting protein losing enteropathy by Tc-99m dextran scintigraphy: a novel experience

Seema Kapoor et al. Indian J Pediatr. 2002 Sep.

Abstract

Objective: To evaluate protien using enteropathy by Tc-99m dextran scintigraphy.

Methods: Methods for detecting protein loss from the intestine revolve around fecal nitrogen excretion, the clearance of alpha-1 antitrypsin in stools and by endoscopic biopsy.

Result: The diagnosis of protein-losing enteropathy (PLE) can also be established by a scintigraphic method that is noninvasive, simple and requires no patient preparation or motivation. This diagnostic modality can also delineate the site of protein loss, thereby offering a targeted approach, and if need be, surgery. Radiolabelling of a non-protein, noncolloidal, nonparticulate and biofriendly molecule like dextran with Technetium-99m for imaging enteric protein loss was utilized in imaging eight children with PLE.

Conclusion: The results were encouraging. The authors advocate the use of this diagnostic tool in identifying patients with PLE, particularly in the pediatric age group.

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