Studies on the intrathecal pharmacotherapy. Part I: CDP-choline
- PMID: 1242132
Studies on the intrathecal pharmacotherapy. Part I: CDP-choline
Abstract
A study was made of the intrathecal infusion as a route of administration of drugs for the CNS, by giving due consideration to the presence of blood-brain and CSF-brain barriers. CDP-choline was used as the brain activator, and the effect of the drug intrathecally infused was investigated both clinically and by experiments on animals. Seven patients with a disturbance of consciousness due to primary brain lesion received a total of 19 intrathecal infusions of CDP-choline, and were examined for the effect of the treatment neurologically and electroencephalographically. Wistar rats were infused either intravascularly or intracisternally with 14C-CDP-choline, and the distribution in the body was investigated by whole body autoradiography.
Similar articles
-
Intrathecal pharmacotherapy in coma.Acta Neurochir (Wien). 1976;34(1-4):37-44. doi: 10.1007/BF01405861. Acta Neurochir (Wien). 1976. PMID: 989256
-
Intrathecal administration of CDP-choline into the lower lumbar subarachnoid space in two patients with post-traumatic akinetic mutism.Fukushima J Med Sci. 1976 Mar;22(1-2):31-47. Fukushima J Med Sci. 1976. PMID: 1037478 No abstract available.
-
Low-resolution autoradiography in rat brain after administering labelled CDP-choline.Arzneimittelforschung. 1983;33(7A):1054-6. Arzneimittelforschung. 1983. PMID: 6684465
-
CDP-choline: pharmacological and clinical review.Methods Find Exp Clin Pharmacol. 1995 Oct;17 Suppl B:1-54. Methods Find Exp Clin Pharmacol. 1995. PMID: 8709678 Review.
-
CDP-choline in the treatment of cranio-encephalic traumata.J Neurol Sci. 1991 Jul;103 Suppl:S43-7. doi: 10.1016/0022-510x(91)90008-u. J Neurol Sci. 1991. PMID: 1940966 Review. No abstract available.
Cited by
-
Interaction of CDP-choline with synaptosomal transport of biogenic amines and their precursors in vitro and in vivo in the rat corpus striatum.Experientia. 1978 Sep 15;34(9):1197-9. doi: 10.1007/BF01922955. Experientia. 1978. PMID: 31297
-
Role of Citicoline in the Management of Traumatic Brain Injury.Pharmaceuticals (Basel). 2021 Apr 26;14(5):410. doi: 10.3390/ph14050410. Pharmaceuticals (Basel). 2021. PMID: 33926011 Free PMC article. Review.
-
Citicoline: pharmacological and clinical review, 2022 update.Rev Neurol. 2022 Nov 30;75(s05):S1-S89. doi: 10.33588/rn.75s05.2022311. Rev Neurol. 2022. PMID: 36544369 Free PMC article. Review. English, Spanish.