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. 2002 Nov 14;4(23):4005-8.
doi: 10.1021/ol020136x.

Soluble alpha-amino acid salts in acetonitrile: practical technology for the production of some dipeptides

Claudio Palomo  1 , Antonio L Palomo, Francisco Palomo, Antonia Mielgo
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Soluble alpha-amino acid salts in acetonitrile: practical technology for the production of some dipeptides

Claudio Palomo et al. Org Lett. .

Abstract

Alpha-amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibitor enalapril. [reaction: see text]

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