Behavioral and biochemical interactions of 5,7-dihydroxytryptamine with various drugs when administered intracisternally to adult and developing rats
- PMID: 1242372
- PMCID: PMC2913872
- DOI: 10.1016/0006-8993(75)90370-4
Behavioral and biochemical interactions of 5,7-dihydroxytryptamine with various drugs when administered intracisternally to adult and developing rats
Abstract
Intracisternal administration of 200 mug of 5,7-dihydroxytryptamine (5,7-DHT) caused a prolonged reduction of brain serotonin which was accompanied by a depletion of brain norepinephrine. The depletion of norepinephrine was found to be antagonized by agents that inhibit uptake of norepinephrine as well as by several monoamine oxidase inhibitors. Intracisternal injections of 5,7-DHT (75 or 100 mug) to 7-day-old neonatal rats reduced brain serotonin and norepinephrine and produced a significant reduction of adult body weight. As in adults, pretreatment of neonatal rats with pargyline or desipramine prevented 5,7-DHT induced depletion of norepinephrine without affecting depletion of serotonin. Behaviorally, treatment of adult rats with 5,7-DHT facilitated acquisition of an active avoidance task and enhanced muricidal behavior. 5,7-DHT treatment was also found to enhance the depressant effects of 5-hydroxytryptophan on a fixed-ratio barpress response, suggesting that 5,7-DHT treated rats are supersensitive to serotonin in the central nervous system.
Similar articles
-
Biochemical and behavioral alterations in developing rats treated with 5,7-dihydroxytryptamine.J Pharmacol Exp Ther. 1978 Jun;205(3):587-95. J Pharmacol Exp Ther. 1978. PMID: 307057
-
Biochemical and behavioural alterations following 5,6-dihydroxytryptamine administration into brain.Neuropharmacology. 1974 Mar;13(3):177-87. doi: 10.1016/0028-3908(74)90105-1. Neuropharmacology. 1974. PMID: 4407423 No abstract available.
-
Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles.Pharmacol Biochem Behav. 1976 Jul;5(1):63-72. doi: 10.1016/0091-3057(76)90289-6. Pharmacol Biochem Behav. 1976. PMID: 996042
-
Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.Brain Res. 1978 Oct 27;155(2):263-75. doi: 10.1016/0006-8993(78)91022-3. Brain Res. 1978. PMID: 308387
-
Degenerative effects of various neurotoxic indoleamines on central monoamine neurons.Ann N Y Acad Sci. 1978 Jun 12;305:305-27. doi: 10.1111/j.1749-6632.1978.tb31531.x. Ann N Y Acad Sci. 1978. PMID: 360938 Review. No abstract available.
Cited by
-
Evidence against serotonin involvement in the tonic component of electrically induced convulsions and in carbamazepine anticonvulsant activity.Psychopharmacology (Berl). 1979;66(1):79-85. doi: 10.1007/BF00431994. Psychopharmacology (Berl). 1979. PMID: 120546
-
Animal violence demystified.Front Behav Neurosci. 2010 Apr 5;4:9. doi: 10.3389/fnbeh.2010.00009. eCollection 2010. Front Behav Neurosci. 2010. PMID: 20407576 Free PMC article.
-
Supersensitivity to L-5-hydroxytryptophan after 5,7-dihydroxytryptamine injections in desmethylimipramine- and nomifensine-pretreated rats: behavioral evidence for postsynaptic supersensitivity.Psychopharmacology (Berl). 1981;74(2):109-14. doi: 10.1007/BF00432674. Psychopharmacology (Berl). 1981. PMID: 6115443
-
Importance of the Locus coeruleus and involvement of alpha-adrenergic receptors in the post-decapitation reflex in the rat.Psychopharmacology (Berl). 1980;69(2):163-71. doi: 10.1007/BF00427644. Psychopharmacology (Berl). 1980. PMID: 6256789
-
Serotonergic intraventricular axons in the habenular region. Phagocytosis after induced degeneration.Anat Embryol (Berl). 1980;158(2):213-26. doi: 10.1007/BF00315907. Anat Embryol (Berl). 1980. PMID: 7356178
References
-
- Aprison MH, Ferster CB. Neurochemical correlates of behavior: correlation of brain monoamine oxidase activity with behavioral changes after iproniazid and 5-hydroxytryptophan. J. Neurochem. 1961;6:350–357. - PubMed
-
- Baumgarten HG, Björklund A, Holstein AF, Nobin A. Chemical degeneration of inolamine axons in rat brain by 5,6-dihydroxytryptamine; an ultrastructural study. Z. Zellforsch. 1972;129:256–271. - PubMed
-
- Baumgarten HG, Björklund A, Lachenmayer L, Nobin A, Stenevi U. Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine. Acta physiol, scand. 1971 Suppl. 373:1–15. - PubMed
-
- Baumgarten HG, Björklund A, Lachenmayer L, Nobin A. Evaluation of the effects of 5,7-dihydroxytryptamine on serotonin and catecholamine neurons in the rat CNS. Acta physiol. scand. 1973 Suppl. 391:1–19. - PubMed
-
- Baumgarten HG, Björklund A, Lachenmayer L, Rensch A, Rosengren E. De- and regeneration of the bulbospinal serotonin neurons in the rat following 5,6-dihydroxytryptamine treatment. Cell Tissue Res. 1974;152:271–281. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials