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Review
. 2002 May-Jun;84(5-6):391-7.
doi: 10.1016/s0300-9084(02)01419-0.

The Tol proteins of Escherichia coli and their involvement in the translocation of group A colicins

Jean-Claude Lazzaroni  1 , Jean-François Dubuisson, Anne Vianney
Affiliations
Review

The Tol proteins of Escherichia coli and their involvement in the translocation of group A colicins

Jean-Claude Lazzaroni et al. Biochimie. 2002 May-Jun.

Abstract

The Tol proteins are involved in outer membrane stability of Gram-negative bacteria. The TolQRA proteins form a complex in the inner membrane while TolB and Pal interact near the outer membrane. These two complexes are transiently connected by an energy-dependent interaction between Pal and TolA. The Tol proteins have been parasitized by group A colicins for their translocation through the cell envelope. Recent advances in the structure and energetics of the Tol system, as well as the interactions between the N-terminal translocation domain of colicins and the Tol proteins are presented.

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