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Case Reports
. 2002 Nov;122(5):1858-60.
doi: 10.1378/chest.122.5.1858.

Lung injury linked to etanercept therapy

Laura Peno-Green  1 , Geronomo Lluberas, Thomas Kingsley, Steven Brantley
Affiliations
Case Reports

Lung injury linked to etanercept therapy

Laura Peno-Green et al. Chest. 2002 Nov.

Abstract

Etanercept is the first anticytokine drug approved to treat rheumatoid arthritis. Side effects are infrequent, the most common being local skin reactions, headaches, and upper respiratory tract symptoms. We report the first case of lung injury that occurred while receiving this agent. Biopsy specimens of lung and skin lesions demonstrated noncaseating granulomas associated with a microscopic particulate. Withdrawal of etanercept achieved clinical stabilization, and the addition of prednisone resulted in rapid improvement.

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Comment in

  • Etanercept or mycobacterium lung injury?
    Fennelly K, Iseman MD. Fennelly K, et al. Chest. 2003 Sep;124(3):1174; author reply 1174-5. doi: 10.1378/chest.124.3.1174. Chest. 2003. PMID: 12970055 No abstract available.

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