Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2002 Oct;24(5):201-4.
doi: 10.1023/a:1020555321857.

The potential interaction between oral anticoagulants and acetaminophen in everyday practice

P M L A van den Bemt  1 , L M Geven, N A Kuitert, A Risselada, J R B J Brouwers
Affiliations
Comparative Study

The potential interaction between oral anticoagulants and acetaminophen in everyday practice

P M L A van den Bemt et al. Pharm World Sci. 2002 Oct.

Abstract

Objective: The drug-drug interaction between oral anticoagulants (especially warfarin) and acetaminophen has been described, but evidence is conflicting and evidence for a similar interaction between acenocoumarol or phenprocoumon and acetaminophen is limited. Therefore, a study was performed to determine the influence of acetaminophen on oral anticoagulation with acenocoumarol or phenprocoumon in everyday practice.

Method: Included were patients from two Dutch anticoagulant clinics who had used oral anticoagulants for at least three months and who started with acetaminophen (case group) or benzodiazepines (control group).

Results: Fifty-four patients were included who had a first prescription of acetaminophen in their pharmacy record (during oral anticoagulant use) and twenty patients with a first prescription of a benzodiazepine (during oral anticoagulant use). The INR (International Normalized Ratio) difference before and after acetaminophen use was not statistically significant between the two groups and showed no dose dependency.

Conclusion: These data do not demonstrate that acetaminophen, in the dosages used in everyday practice, has a clinically relevant influence on the INR in patients using acenocoumarol or phenprocoumon.

PubMed Disclaimer

References

    1. J Clin Pharmacol. 1999 Jan;39(1):68-75 - PubMed
    1. Ann Pharmacother. 1999 Apr;33(4):506 - PubMed
    1. Lancet. 1999 Feb 27;353(9154):717-9 - PubMed
    1. Pharmacotherapy. 2000 Dec;20(12):1464-8 - PubMed
    1. Thromb Haemost. 2001 Aug;86(2):563-8 - PubMed

LinkOut - more resources