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. 2002 Dec;51(6):781-6.
doi: 10.1136/gut.51.6.781.

SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication. Single photon emission computed tomography

E P Bouras  1 , S Delgado-Aros, M Camilleri, E J Castillo, D D Burton, G M Thomforde, H J Chial
Affiliations

SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication. Single photon emission computed tomography

E P Bouras et al. Gut. 2002 Dec.

Abstract

Background: Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes.

Aims and methods: Our aims were: to assess the accuracy of SPECT with three dimensional image analysis to measure balloon volumes in vitro; to compare gastric barostat balloon volumes measured post-meal and post-distension with total gastric volumes measured simultaneously with SPECT; to present normal gastric volume data for healthy adults; and to compare SPECT data in health with symptomatic post-fundoplication patients.

Results: In vitro balloon volumes measured by SPECT were highly accurate (R(2)=0.99). When measured simultaneously by gastric barostat and SPECT, postprandial/fasting volume ratios (2.2 (0.12) (mean (SEM)) v 2.3 (0.15), respectively; p=0.6) and post-distension volume ratios (1.4 (0.1) v1.3 (0.1); p=0.2) were highly comparable. In females, postprandial gastric volumes (675 (14) v 744 (20) ml for males; p=0.004) and changes in gastric volumes (464 (14) ml v 521 (20) ml for males; p=0.01) measured by SPECT were significantly lower than in males. No effects of age or body mass index were noted. The postprandial/fasting gastric volume ratio by SPECT was lower in post-fundoplication patients (2.7 (0.2)) than in healthy controls (3.4 (0.1); p=0.003).

Conclusions: SPECT provides a non-invasive estimate of the effect of a meal on total gastric volume that is comparable to changes in balloon volume observed with the gastric barostat. The SPECT technique is promising for investigation of gastric volumes in health and disease and the effects of pharmacological agents.

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Figures

Figure 1
Figure 1
Single photon emission computed tomography (SPECT) data handling and analysis. Multiple transaxial SPECT images (A) were summed and reconstructed via a semiautomated algorithm using the ANALYZE PC 2.5 software system (B) into a three dimensional rendering of the stomach (C) for subsequent measurements of gastric volumes.
Figure 2
Figure 2
Experimental design for simultaneous assessment of volume changes using the gastric barostat and single photon emission computed tomography (SPECT).
Figure 3
Figure 3
Correlation of known balloon volumes with volumes measured in vitro by single photon emission computed tomography (SPECT).
Figure 4
Figure 4
Correlation of postprandial accommodation ratios, as measured by single photon emission computed tomography (SPECT) and gastric barostat.
Figure 5
Figure 5
Postprandial to fasting gastric volume ratio in health and post-fundoplication symptomatic patients. Note the overall difference in the two groups but the significant overlap of data for a sizable proportion of patients with data from healthy controls.
See this image and copyright information in PMC

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