Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Jul-Aug;1(4):255-7.

Mitotic regulation: the fine tuning of separase activity

Ritu Agarwal  1 , Orna Cohen-Fix
Affiliations
  • PMID: 12429942
Review

Mitotic regulation: the fine tuning of separase activity

Ritu Agarwal et al. Cell Cycle. 2002 Jul-Aug.

Abstract

Mitotic progression requires the dissolution of cohesion between sister chromatids. Cohesion is dissolved by an essential protease known as separase. Separase is highly conserved throughout evolution and is subjected to multiple levels of regulation. Here we discuss recent studies that unravel several key mechanisms for regulating separase activity.

PubMed Disclaimer

Comment in