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. 1975 Oct;25(10):1606-8.

[Teratogenic action of ethyl-nitrosourea in Göttingen miniature pigs (author's transl)]

[Article in German]
J Graw, S Ivankovic, H Berg, D Schmähl
  • PMID: 1243047

[Teratogenic action of ethyl-nitrosourea in Göttingen miniature pigs (author's transl)]

[Article in German]
J Graw et al. Arzneimittelforschung. 1975 Oct.

Abstract

By i.p. application of 70 or 100 mg/kg ethyl-nitrosourea, resp., to gravide Göttingen miniature pigs on days 14 or 16, resp., of gestation massive malformations of the skeletal system were produced. The experiments demonstrated the teratogenic effect of ethylnitrosourea on non-rodents, ascertained the period of determination of the skeletal system in pigs, confirmed the concentration effect in teratogenesis as well as the ineffectiveness of biological barriers with adequately high dosages.

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