[Cardiovascular effects of glycerol-1-(2-diethyl-amino-ethylether)-3-(2-methoxyphenylether) in the anaesthetized cat (author's transl)]

Abstract

The cardiovascular effects of a new antiarrhythmic drug derived from the local anaesthetics glycerol-1-(2-diethylaminoethylether)-3-(2-methoxyphenylether) (Brufacain), was examined on 10 anaesthetized cats and compared in parallel experiments to alpha-diethylamino-acetate-2,6-xylidide (lidocaine). The following parameters were determined: 1. ventricular fibrillation threshold, 2. ECG, 3. systolic and diastolic blood pressure, 4. cardiac output. Both agents increased the ventricular fibrillation threshold: Brufacain and lidocaine led to a significant deviation up to 50 min after the end of the infection. In the ECG the P-P distance after 10 and 20 min for Brufacain and after 20 min for lidocaine was significantly prolonged. The ECG showed for lidocaine a shortening of the QRS complex after the 40th min and for Brufacain initially a Q-T prolongation, both with statistical significance. A significant increase in blood pressure was noted 30 and 40 min after the injection of Brufacain. Lidocaine caused a significant decrease in blood pressure beginning 10 min after the injection. The cardiac output was significantly decreased 10, 30, 50 and 60 min after administration of Brufacain and 10 and 40 min after administration of lidocaine.