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. 2002 Nov 13:3:35.
doi: 10.1186/1471-2105-3-35. Epub 2002 Nov 13.

FunSpec: a web-based cluster interpreter for yeast

Mark D Robinson  1 , Jörg Grigull, Naveed Mohammad, Timothy R Hughes
Affiliations

FunSpec: a web-based cluster interpreter for yeast

Mark D Robinson et al. BMC Bioinformatics. .

Abstract

Background: For effective exposition of biological information, especially with regard to analysis of large-scale data types, researchers need immediate access to multiple categorical knowledge bases and need summary information presented to them on collections of genes, as opposed to the typical one gene at a time.

Results: We present here a web-based tool (FunSpec) for statistical evaluation of groups of genes and proteins (e.g. co-regulated genes, protein complexes, genetic interactors) with respect to existing annotations (e.g. functional roles, biochemical properties, localization). FunSpec is available online at http://funspec.med.utoronto.ca

Conclusion: FunSpec is helpful for interpretation of any data type that generates groups of related genes and proteins, such as gene expression clustering and protein complexes, and is useful for predictive methods employing "guilt-by-association."

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Figures

Figure 1
Figure 1
A 2-D clustering analysis of yeast gene expression data from [8].
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