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Review
. 2002 Dec 15;115(Pt 24):4721-6.
doi: 10.1242/jcs.00218.

The Ena/VASP enigma

Matthias Krause  1 , James E Bear, Joseph J Loureiro, Frank B Gertler
Affiliations
Review

The Ena/VASP enigma

Matthias Krause et al. J Cell Sci. .

Abstract

Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments.

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