Review
doi: 10.1016/s0090-6980(02)00029-1.
Distinct functions of COX-1 and COX-2
Affiliations
- PMID: 12432916
- DOI: 10.1016/s0090-6980(02)00029-1
Item in Clipboard
Review
Distinct functions of COX-1 and COX-2
Prostaglandins Other Lipid Mediat.
2002 Aug.
Abstract
The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-1 (COX-1) and COX-2. The properties of COX-1 are different from those of COX-2. It was originally thought that the function of COX-1 was involved in physiological phenomena, whereas that of COX-2 was involved in various pathologies. However, studies with COX-2 knockout mouse suggest that COX-2 also plays important roles in development and homeostasis. This chapter focuses on the distinct functions of COX-1 and COX-2.
Similar articles
-
Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:177-85. doi: 10.1016/s0090-6980(02)00028-x. Prostaglandins Other Lipid Mediat. 2002. PMID: 12432917 Review.
-
[Arachidonic acid and prostaglandins, inflammation and oncology].Presse Med. 2001 Mar 17;30(10):508-10. Presse Med. 2001. PMID: 11307496 French.
-
Regulation of cyclo-oxygenase-2.Best Pract Res Clin Gastroenterol. 2001 Oct;15(5):787-800. doi: 10.1053/bega.2001.0235. Best Pract Res Clin Gastroenterol. 2001. PMID: 11566041 Review.
-
Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors.Clin Cancer Res. 2003 May;9(5):1604-10. Clin Cancer Res. 2003. PMID: 12738712
-
Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse).Am J Physiol Renal Physiol. 2003 Jul;285(1):F19-32. doi: 10.1152/ajprenal.00443.2002. Epub 2003 Mar 25. Am J Physiol Renal Physiol. 2003. PMID: 12657565
Cited by
-
Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways.Inflammation. 2017 Feb;40(1):1-12. doi: 10.1007/s10753-016-0447-7. Inflammation. 2017. PMID: 27718095
-
Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages.Molecules. 2018 Aug 23;23(9):2124. doi: 10.3390/molecules23092124. Molecules. 2018. PMID: 30142934 Free PMC article.
-
Anti-Inflammatory Effects of Huberia peruviana Cogn. Methanol Extract by Inhibiting Src Activity in the NF-κB Pathway.Plants (Basel). 2021 Oct 29;10(11):2335. doi: 10.3390/plants10112335. Plants (Basel). 2021. PMID: 34834697 Free PMC article.
-
Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity.Eur J Med Chem. 2023 Nov 15;260:115724. doi: 10.1016/j.ejmech.2023.115724. Epub 2023 Aug 15. Eur J Med Chem. 2023. PMID: 37611534 Free PMC article.
-
Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice.PLoS One. 2018 Nov 6;13(11):e0207085. doi: 10.1371/journal.pone.0207085. eCollection 2018. PLoS One. 2018. PMID: 30399192 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
