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. 2002 Oct;25(5):628-35.
doi: 10.1007/BF02976934.

Phytochemical constituents of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines

Won Bin Lee, Hak Cheol Kwon, Ock Ryun Cho, Kang Choon Lee, Sang Un Choi, Nam In Baek, Kang Ro Lee

Phytochemical constituents of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines

Won Bin Lee et al. Arch Pharm Res. 2002 Oct.

Abstract

Five terpenes (1-5), three fatty acids (6-8), two sterols (9 and 11), and a monogalactosyldiacyl glycerol (10) were isolated from the methylene chloride extract of the aerial part of Cirsium setidens. Their chemical structures were determined to be alpha-tocopherol (1), 25-hydroperoxycycloart-23-en-3beta-ol (2), 24-hydroperoxycycloart-25-en-3beta-ol (3), mokko lactone (4), transphytol (5), 9,12,15-octadecatrienoic acid (6), 9,12-octadecadienoic acid (7), hexadecanoic acid (8), acylglycosyl beta-sitosterol (9), (2R)-1,2-O-(9z,12z,15z-dioctadecatrienoyl)-3-O-beta-D-galactopyranosyl glycerol (10) and beta-sitosterol glucoside (11) by spectral evidences. Compound 3 exhibited significant cytotoxic activity against five human cancer cell lines with its ED50 values ranging from 2.66 to 11.25 microM.

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