Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Nov;17(5):537-47.
doi: 10.1016/s1074-7613(02)00429-6.

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

Sigrid Dubois  1 , Jennifer Mariner, Thomas A Waldmann, Yutaka Tagaya
Affiliations
Free article

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

Sigrid Dubois et al. Immunity. 2002 Nov.
Free article

Abstract

We report intriguing aspects of the contribution of IL-15Ralpha to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15Ralpha, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Ralpha complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constant reappearance of IL-15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL-15Ralpha after IL-15 withdrawal. Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8(+) T cells that express only IL-2/15Rbeta and gammac upon cell-cell interaction.

PubMed Disclaimer