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. 2002 Nov;22(11):1003-4.

[Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro]

[Article in Chinese]
Zhi-Ping L  1 , Qiang Liu, Xin-Wei Lu
Affiliations
  • PMID: 12433630

[Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro]

[Article in Chinese]
Zhi-Ping L et al. Di Yi Jun Yi Da Xue Xue Bao. 2002 Nov.

Abstract

Objective: To study the effects of azone on the percutaneous absorption of baicalin in vitro.

Methods: Using the skin of nude mice as the cutaneous barrier, the rate constants of percutaneous absorption of baicalin at various concentrations of Azone were determined.

Results: The rate constants were 76.07, 89.23, 167.36, 238.61, 200.45 and 171.49 microgram cm-2.h-1 respectively corresponding to the concentrations of Azone at 0, 2%, 4%, 6%, 8%, and 10%.

Conclusion: C Azone can enhance percutaneous absorption of baicalin, exerting its maximum effect at the concentration of 6%.

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