doi: 10.1113/jphysiol.1975.sp010822.
The interaction of ATP-analogues possessing a blocked gamma-phosphate group with the sodium pump in human red cells
- PMID: 124351
- PMCID: PMC1330832
- DOI: 10.1113/jphysiol.1975.sp010822
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The interaction of ATP-analogues possessing a blocked gamma-phosphate group with the sodium pump in human red cells
J Physiol.
1975 Jan.
Abstract
1. The (Na++K+)-ATPase of red cell membranes is unable to hydrolyse ATP-analogues in which the oxygen atom linking the beta- and gamma-phosphate groups is replaced by a minusCH2minus or minusNH-bridge. 2. In resealed ghosts both these ATP-analogues support K:K exchange but not Na:K exchange. ATP supports both modes of operation of the sodium pump, whereas neither occurs without any nucleotide. 3. These results support the hypothesis that ATP is needed as a cofactor for K:K exchange to occur, and make it extremely unlikely that phosphorylation from ATP is involved.
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