[Kinetics of resorption in the cochlear perilymph after charging with radionuclides (author's transl)]

Abstract

The perilymphatic space of the guinea pig's cochlea is filled within 1 to 3 min with an isotonic Ringer solution labelled with a radionuclide. The cochlea is neatly sealed immediately afterwards, thus causing only a minimal disturbance in the inner ear. The animal's cochlea is brought into the strict focus of a small detector as quickly as possible, the decay of activity is continuously controlled for 2 to 10 hrs. The radionuclides used are Cl36, Na22, and Tc99m. The decay of activity of the cochlea is strongly believed to accord to a simple exponential law; half lives range from about one to about three hours. Cl36 and Tc99m were used for the first time in studying cochlear kinetics.