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. 2002 Dec;46(12):3997-9.
doi: 10.1128/AAC.46.12.3997-3999.2002.

In vitro killing effect of moxifloxacin on clinical isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole

Evangelos J Giamarellos-Bourboulis  1 , Lazaros Karnesis, Irene Galani, Helen Giamarellou
Affiliations

In vitro killing effect of moxifloxacin on clinical isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole

Evangelos J Giamarellos-Bourboulis et al. Antimicrob Agents Chemother. 2002 Dec.

Abstract

The time-kill effect of moxifloxacin on 20 genetically distinct isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole was studied. The majority (80%) were killed by a concentration equivalent to four times the MIC; the MIC induced a transient decrease in bacterial counts at 4 h, followed by regrowth. No effect was detected in four isolates. These results merit further clinical consideration.

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Figures

FIG. 1.
FIG. 1.
PFGE of the 20 isolates of S. maltophilia tested in this study.
See this image and copyright information in PMC

References

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