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. 2002 Dec;46(12):4026-8.
doi: 10.1128/AAC.46.12.4026-4028.2002.

Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa

Spyros Pournaras  1 , Athanassios Tsakris, Maria Maniati, Leonidas S Tzouvelekis, Antonios N Maniatis
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Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa

Spyros Pournaras et al. Antimicrob Agents Chemother. 2002 Dec.

Abstract

A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with postsurgical cerebrospinal infection in Greece. The isolate carried a class 1 integron that contained as a sole cassette the gene bla(VIM-4), a novel variant of bla(VIM-1), with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy.

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