Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Nov;151(2):337-49.
doi: 10.1042/bj1510337.

Sequence studies on the constant region of the Fd sections of rabbit immunoglobulin G of different allotype

D M Pratt, L E Mole

Sequence studies on the constant region of the Fd sections of rabbit immunoglobulin G of different allotype

D M Pratt et al. Biochem J. 1975 Nov.

Abstract

The amino acid sequence has been completed for the constant region of the Fd fragments of heavy chains from rabbit IgG (immunoglobulin G) of allotype Aa1 and Aa3. The amino acid sequence given by Fruchter et al. [(1970) Biochem. J. 116, 249-259] for the constant region of the Fd fragment from Aa1 IgG was extended and in in part corrected to give a continuous sequence of 140 residues. No allotype-related sequence variation was found in the constant section of the Fd fragment. This evidence confirms the view that the differences in sequence between the variable regions of Aa1 and Aa3 IgG [Mole et al., (1971) Biochem. J. 124, 301-318] are responsible for the allotypic specificities.

PubMed Disclaimer

References

    1. J Biol Chem. 1962 Aug;237:2547-61 - PubMed
    1. Biochemistry. 1971 Jul 6;10(14):2753-61 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 Sep;54(3):864-9 - PubMed
    1. J Exp Med. 1969 Sep 1;130(3):619-42 - PubMed
    1. Biochem Biophys Res Commun. 1963 May 3;11:170-5 - PubMed