Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Oct 9:1:2.
doi: 10.1186/1476-0711-1-2.

Susceptibility patterns and cross resistances of antibiotics against Pseudomonas aeruginosa in a teaching hospital of Turkey

Serap Gençer  1 , Oznur Ak, Nur Benzonana, Ayşe Batirel, Serdar Ozer
Affiliations

Susceptibility patterns and cross resistances of antibiotics against Pseudomonas aeruginosa in a teaching hospital of Turkey

Serap Gençer et al. Ann Clin Microbiol Antimicrob. .

Abstract

Background: Pseudomonas aeruginosa is the third most common pathogen responsible for nosocomial infections and the prevalence of multiple resistant isolates has been increasing. Ninety-nine clinical isolates were studied in order to assess the current levels of susceptibility and cross-resistances of widely used antipseudomonal antibiotics against P. aeruginosa and to determine some resistance mechanisms by phenotypic methods.

Methods: MICs of isolates for nine antipseudomonal antibiotics were determined by the E test method.

Results: Thirty-six percent of isolates were resistant to more than one group of antibiotics. The rates of susceptible isolates were ciprofloxacin 75%, amikacin 73%, ceftazidime 65%, meropenem 63%, imipenem 63%, piperacillin/tazobactam 60%, cefoperazone/sulbactam 59%, cefepime 54% and tobramycin 44%. The majority of carbapenem resistant isolates were susceptible to ciprofloxacin and amikacin.

Conclusion: Ciprofloxacin seems to be the most active agent against P. aeruginosa followed by amikacin in our unit. The usefulness of combinations of these antibiotics and beta-lactams should be tested in treating multi-drug resistant P. aeruginosa.

PubMed Disclaimer

References

    1. Gençer S, Benzonana N, Özer S, Kuzu İ, Özyurt Y. Cerrahi Yoğun Bakım Ünitesinden izole edilen bakteriler ve antibiyotik duyarlılıkları. Yoğun Bakım Dergisi. 2001;1:131–137.
    1. National Committee for Clinical Laboratory Standards Performance Standards for Antimicrobial Susceptibility Testing; Eight Informational Supplement M100-S8. NCCLS, Villanova, PA. 1998.
    1. Sanders CC, Sanders WE. β-lactam resistance in gram-negative bacteria: global trends and clinical impact. Clin Infect Dis. 1992;15:824–839. - PubMed
    1. Livermore DM. β-lactamases in laboratory and clinical resistance. Clin Microbiol Rev. 1995;8:567–584. - PMC - PubMed
    1. Lee K, Chong Y, Shin HB, Kim YA, Yong D, Yum JH. Modified Hodge and EDTA-disk synergy tests to screen metallo-β-lactamase-producing strains of Pseudomonas and Acinetobacter species. Clin Microbiol Infect. 2001;7:88–91. doi: 10.1046/j.1469-0691.2001.00204.x. - DOI - PubMed

LinkOut - more resources