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. 2002 Oct:971:153-5.
doi: 10.1111/j.1749-6632.2002.tb04453.x.

Serum deprivation-induced upregulation of voltage-dependent sodium channels in adrenal chromaffin cells: selective involvement of extracellular signal-regulated kinase pathway

Toshihiko Yanagita  1 , Hideyuki Kobayashi, Hiroki Yokoo, Tomokazu Saitoh, Shin-Ichi Minami, Seiji Shiraishi, Yasuhito Uezono, Akihiko Wada
Affiliations

Serum deprivation-induced upregulation of voltage-dependent sodium channels in adrenal chromaffin cells: selective involvement of extracellular signal-regulated kinase pathway

Toshihiko Yanagita et al. Ann N Y Acad Sci. 2002 Oct.

Abstract

In the present study, we investigated whether activation of the MAPK family could regulate the cell surface expression of Na channels in cultured bovine adrenal chromaffin cells. The results suggest that constitutively activated ERK (but not p38 or JNK), by various extracellular stimuli, down-modulates the density of cell surface Na channels, which was mediated via the destabilization of Na channel alpha-subunit mRNA.

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