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Comment
. 2002 Nov 18;196(10):1271-5.
doi: 10.1084/jem.20021572.

Interactions between RSV infection, asthma, and atopy: unraveling the complexities

P G Holt  1 , P D Sly
Affiliations
Comment

Interactions between RSV infection, asthma, and atopy: unraveling the complexities

P G Holt et al. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Age-related changes in adaptive immune responses to RSV infection as potential aetiologic factors in acute bronchiolitis and later asthma. In this scheme, the Th1/Th2 “bias” in the adaptive immune response to initial infection with RSV is determined by age, in particular, the contribution of the Th1 component is inversely related to postnatal age at infection onset. The degree of the Th2 bias during infancy is exaggerated in a subset of subjects, increasing their risk for severe RSV infection which spreads to the lower airways and triggers wheeze, and also increasing their risk for development of respiratory allergy. Epidemiological data from large birth cohort studies (exemplified by the data in the inset from reference 16) indicate that maximal risk for early development of persistent asthma involves a history of concomitant wheezing lower respiratory tract infections(wLRI) during infancy together with atopic sensitization to aeroallergens, suggesting that damage to developing airways via these two pathways acting in synergy, drives the disease process.
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