Review
doi: 10.1016/s0079-6123(02)37026-2.
Increasing plasticity and functional recovery of the lesioned spinal cord
Affiliations
- PMID: 12440377
- DOI: 10.1016/s0079-6123(02)37026-2
Item in Clipboard
Review
Increasing plasticity and functional recovery of the lesioned spinal cord
Prog Brain Res.
2002.
Abstract
In vitro assays have shown that adult CNS tissue, in particular oligodendrocytes and myelin, contains several molecular constituents (Nogo-A/NI-220, MAG, several proteoglycans) which exert neurite growth inhibitory activity. Elimination of oligodendrocytes or myelin, or application of antibodies against some of these constituents enhance regenerative growth and compensatory sprouting of lesioned and unlesioned fiber tracts in spinal cord and brain. Enhanced growth is paralleled by various degrees of functional recovery.
Similar articles
-
Regenerating corticospinal fibers in the Marmoset (Callitrix jacchus) after spinal cord lesion and treatment with the anti-Nogo-A antibody IN-1.Eur J Neurosci. 2004 Nov;20(9):2479-82. doi: 10.1111/j.1460-9568.2004.03716.x. Eur J Neurosci. 2004. PMID: 15525289
-
Immunization with recombinant Nogo-66 receptor (NgR) promotes axonal regeneration and recovery of function after spinal cord injury in rats.Neurobiol Dis. 2008 Dec;32(3):535-42. doi: 10.1016/j.nbd.2008.09.012. Epub 2008 Sep 30. Neurobiol Dis. 2008. PMID: 18930141
-
Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions.Nat Neurosci. 1998 Jun;1(2):124-31. doi: 10.1038/373. Nat Neurosci. 1998. PMID: 10195127
-
Overcoming inhibition in the damaged spinal cord.J Neurotrauma. 2006 Mar-Apr;23(3-4):371-83. doi: 10.1089/neu.2006.23.371. J Neurotrauma. 2006. PMID: 16629623 Review.
-
Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system.Ann Med. 2005;37(8):556-67. doi: 10.1080/07853890500407520. Ann Med. 2005. PMID: 16338758 Review.
Cited by
-
Role of glial cells in axonal regeneration.Exp Neurobiol. 2013 Jun;22(2):68-76. doi: 10.5607/en.2013.22.2.68. Epub 2013 Jun 27. Exp Neurobiol. 2013. PMID: 23833555 Free PMC article.
-
An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells.J Neurosci. 2004 May 26;24(21):4989-99. doi: 10.1523/JNEUROSCI.4390-03.2004. J Neurosci. 2004. PMID: 15163691 Free PMC article.
-
Proteomic analysis of the dorsal spinal cord in the mouse model of spared nerve injury-induced neuropathic pain.J Biomed Res. 2017 Sep 3;31(6):494-502. doi: 10.7555/JBR.31.20160122. Online ahead of print. J Biomed Res. 2017. PMID: 28866658 Free PMC article.
-
Cellular expression profile of RhoA in rats with spinal cord injury.J Huazhong Univ Sci Technolog Med Sci. 2014 Oct;34(5):657-662. doi: 10.1007/s11596-014-1333-x. Epub 2014 Oct 16. J Huazhong Univ Sci Technolog Med Sci. 2014. PMID: 25318874
-
Chronic cocaine administration causes extensive white matter damage in brain: diffusion tensor imaging and immunohistochemistry studies.Psychiatry Res. 2014 Mar 30;221(3):220-30. doi: 10.1016/j.pscychresns.2014.01.005. Epub 2014 Jan 23. Psychiatry Res. 2014. PMID: 24507117 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
