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. 2002 Nov 22;324(2):359-71.
doi: 10.1016/s0022-2836(02)01029-x.

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A Krantz  1 , Leland Mayne, Jon Rumbley, S Walter Englander, Tobin R Sosnick
Affiliations

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A Krantz et al. J Mol Biol. .

Abstract

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

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