Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Dec 1;311(1):33-9.
doi: 10.1016/s0003-2697(02)00386-x.

Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry

Markus Stoeckli  1 , Dieter Staab, Matthias Staufenbiel, Karl-Heinz Wiederhold, Luca Signor
Affiliations

Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry

Markus Stoeckli et al. Anal Biochem. .

Abstract

A method is presented for direct spatial analysis of amyloid beta peptides in biological tissue sections. The technique takes advantage of the very high sensitivity of matrix-assisted laser desorption/ionization mass spectrometry and is implemented on a commercial instrument with modifications to only a few components and the software. With this setup, hundreds of molecular images can be generated simultaneously and within just a few minutes. The current features are an instrumental resolution of 50 microm and a sensitivity down to the attomol range. This new technology is applied to the study of amyloid beta peptide distribution in brain sections from mice, showing features reminiscent of Alzheimer's disease.

PubMed Disclaimer

MeSH terms