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. 1975;29(1-6):79-84.

Effect of clozapine on 5-HIAA excretion in urine and CSF of psychotic patients and on serotonin metabolism in rat brain

M Ackenheil, B Blatt, C Lampart
  • PMID: 1244129

Effect of clozapine on 5-HIAA excretion in urine and CSF of psychotic patients and on serotonin metabolism in rat brain

M Ackenheil et al. Acta Vitaminol Enzymol. 1975.

Abstract

In a clinical study and with experiments in rats Clozapine showed a sedative effect, which diminished during the treatment, and indicated a development of tolerance. 5-HIAA in urine and CSF of patients was elevated after 10 days of treatment. 5-HT and 5-HIAA were elevated in the brains of rats in acute experiments as well as in chronic experiments.

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