Genetic basis of neural tube defects. II. Genes correlated with folate and methionine metabolism
- PMID: 12441636
Genetic basis of neural tube defects. II. Genes correlated with folate and methionine metabolism
Abstract
Effective supplementation with folate, which prevents neural tube defect (NTD) occurrence, and high homocysteine levels in the blood of NTD children's mothers suggest that genes involved in folate and homocysteine metabolism can be involved in NTD aetiology. Genes encoding methylenetetrahydrofolate reductase (MTHFR) or methylenetetrahydrofolate dehydrogenase (MTHFD) belong to the first group. Genes encoding methionine synthase (MTR), its regulator - methionine synthase reductase (MTRR) and also cystathionine synthase (CBS) can be included in the second group. We present a current list of the folate and homocysteine metabolism genes that are known to be involved in NTD and pay special attention to primary and secondary NTD prevention.
Similar articles
-
[Genetic risk factors of neural tube defects].Med Wieku Rozwoj. 2002 Oct-Dec;6(4):349-70. Med Wieku Rozwoj. 2002. PMID: 12810987 Review. Polish.
-
Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population.J Hum Genet. 2001;46(3):105-9. doi: 10.1007/s100380170096. J Hum Genet. 2001. PMID: 11310576
-
Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.Mol Genet Metab. 2000 May;70(1):27-44. doi: 10.1006/mgme.2000.2994. Mol Genet Metab. 2000. PMID: 10833329
-
Homocysteine, folate enzymes and neural tube defects.Haematologica. 1999 Jun;84 Suppl EHA-4:53-6. Haematologica. 1999. PMID: 10907468 Review. No abstract available.
-
Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature.Eur J Obstet Gynecol Reprod Biol. 2006 Feb 1;124(2):130-3. doi: 10.1016/j.ejogrb.2005.07.028. Epub 2005 Oct 5. Eur J Obstet Gynecol Reprod Biol. 2006. PMID: 16169148 Review.
Cited by
-
Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects.J Cancer. 2020 Sep 13;11(21):6413-6420. doi: 10.7150/jca.46978. eCollection 2020. J Cancer. 2020. PMID: 33033524 Free PMC article.
-
Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study.BMC Med Genet. 2011 Mar 7;12:35. doi: 10.1186/1471-2350-12-35. BMC Med Genet. 2011. PMID: 21385350 Free PMC article.
-
Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits.BMC Geriatr. 2015 Jul 11;15:82. doi: 10.1186/s12877-015-0060-x. BMC Geriatr. 2015. PMID: 26163013 Free PMC article.
-
Methotrexate pharmacogenomics.Ann Rheum Dis. 2006 Sep;65(9):1121-3. doi: 10.1136/ard.2006.051789. Ann Rheum Dis. 2006. PMID: 16905578 Free PMC article. Review.
-
Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis.Ann Rheum Dis. 2006 Sep;65(9):1213-8. doi: 10.1136/ard.2005.046797. Epub 2006 Jan 26. Ann Rheum Dis. 2006. PMID: 16439441 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Miscellaneous