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Comparative Study
. 2002 Dec;5(6):365-8.

Effects of Ginsenoside Rb1 on proliferation of Schwann cells in culture

Xitang Hu  1 , Xiaoxiang Chen, Liangjian Xiong
Affiliations
  • PMID: 12443579
Comparative Study

Effects of Ginsenoside Rb1 on proliferation of Schwann cells in culture

Xitang Hu et al. Chin J Traumatol. 2002 Dec.

Abstract

Objective: To investigate the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells in culture.

Methods: Applying MTT assay and Thymidine incorporation assay, the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells isolated from the sciatic nerve of adult rat were studied.

Results: Ginsenoside Rb(1) (10 microg/ml) significantly induced Schwann cell proliferation, the effect was similar to NGF (50 microg/ml). At high concentrations of Ginsenoside Rb(1) (1 mg/ml), the proliferation of Schwann cells was significantly inhibited.

Conclusions: Ginsenoside Rb(1) at the optimal concentrations is found to be effective in inducing the proliferation of Schwann cells, but at higher concentrations the drug is cytotoxic for Schwann cells.

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