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. 2002 Dec 16;12(24):3591-4.
doi: 10.1016/s0960-894x(02)00784-9.

Reductively activated disulfide prodrugs of paclitaxel

Vivekananda M Vrudhula  1 , John F MacMaster, Zhengong Li, David E Kerr, Peter D Senter
Affiliations

Reductively activated disulfide prodrugs of paclitaxel

Vivekananda M Vrudhula et al. Bioorg Med Chem Lett. .

Abstract

A series of unsymmetrical polar disulfide prodrugs 2-5 of paclitaxel were designed and synthesized as reductively activated prodrugs. These compounds behaved as prodrugs in vitro on L2987 lung carcinoma cells. In vivo evaluation in mice demonstrated that the mutual prodrug 5 with captopril exhibited significant regressions and cures.

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