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Comparative Study
. 2002 Jun;133(6):609-13.
doi: 10.1023/a:1020258531077.

Comparison of the efficacy of cell preparations from embryonic ventral mesencephalon of various prenatal age transplanted intrastriatally to rats with 6-OHDA-induced Parkinsonism

V P Chekhonin  1 , S V Lebedev, T B Dmitrieva, D V Blinov, I P Lazarenko, E A Savchenko, N N Volodin
Affiliations
Comparative Study

Comparison of the efficacy of cell preparations from embryonic ventral mesencephalon of various prenatal age transplanted intrastriatally to rats with 6-OHDA-induced Parkinsonism

V P Chekhonin et al. Bull Exp Biol Med. 2002 Jun.

Abstract

Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis of apomorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy of cell preparations from 8- and lower from 16-17-day-old embryos. These data correlated with histomorphological findings, in particular, with the size of grafts, glial reaction, and the number of dopaminergic neurons in the grafts.

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