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Review
. 2002 Nov;2(5):347-8.
doi: 10.1016/s1535-6108(02)00184-8.

ETV6-NTRK3--Trk-ing the primary event in human secretory breast cancer

David M Euhus  1 , Charles F Timmons, Gail E Tomlinson
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Free article
Review

ETV6-NTRK3--Trk-ing the primary event in human secretory breast cancer

David M Euhus et al. Cancer Cell. 2002 Nov.
Free article

Abstract

In this issue of Cancer Cell, propose a single chromosomal translocation as the cause of a particularly troubling form of breast cancer, secretory carcinoma. They challenge widely held beliefs concerning breast carcinogenesis as well as beliefs concerning the absolute association of specific fusion genes with specific tumor types. Their data highlight the role of Trk signaling in breast cancer and also suggest a target for drug development.

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