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Clinical Trial
. 2002 Dec;47(6):881-4.
doi: 10.1067/mjd.2002.124703.

Treatment of chronic actinic dermatitis with tacrolimus ointment

Naoko Uetsu  1 , Hiroyuki Okamoto, Keiko Fujii, Risa Doi, Takeshi Horio
Affiliations
Clinical Trial

Treatment of chronic actinic dermatitis with tacrolimus ointment

Naoko Uetsu et al. J Am Acad Dermatol. 2002 Dec.

Abstract

Background: Chronic actinic dermatitis (CAD) is difficult to treat. Topical corticosteroids induce adverse effects after long-term use, especially on light-exposed skin.

Objective: Our purpose was to study the effects of tacrolimus ointment in the treatment of elderly patients with CAD.

Methods: In an open trial, 6 male patients between 51 and 80 years old with CAD applied 0.1% tacrolimus ointment twice a day to the face and neck. According to improvements, the frequency of application was reduced. Sunscreen agents were also applied outdoors.

Results: Tacrolimus ointment effectively treated cutaneous changes in all patients. Symptoms were moderately improved in 2 weeks, and greatly in 4 weeks. A brief and localized irritating sensation occurred in all patients, but no other adverse events developed throughout the study course from 0.5 to 2.5 years.

Conclusion: Topical tacrolimus ointment for facial lesions of CAD appears to be effective and well tolerated and may provide long-term benefits.

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